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In addition to systemic benefits, as early as 1940, it was observed that riboflavin could also have local benefits: vaginal administration of riboflavin in ten women via a lactose tablet was shown to result in an increased acidity and a favorable impact on vaginal bacteria through increased growth of acid-forming bacilli and decrease of pathogens 78

thaliana wild type and flavonoid mutant ( tt5 ) plants to UVB radiation led to a significant decrease in K AsA m as well as synthesis of new isoforms of cytosolic APX (Rao et al., 1996)

M., Bulus, T., Gwarzo, M

Additional downstream consequences of RAGE activity can include increased TGF-1 production, epithelial mesenchymal transition, endothelial permeability, and significant systematic inflammation