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Search Method We reviewed the literature for studies on abdominal pain in primary chronic constipation

Transdermal microneedles loaded with allopurinol achieve sustained urate-lowering effects by controlling drug release kinetics while minimizing gastrointestinal side effects observed with oral formulations ( 4 nanoflowers, coupled with hyaluronic acid microneedles, enhance enzyme stability and catalytic activity, effectively reducing serum uric acid levels by 30% in murine models (Hao et al., 2019)

This emphasizes the potential of SEPT9 and HAND1 methylation as promising biomarkers for the diagnosis of CRC, leading to early detection and improved patient outcomes (Shavali et al., 2024)

BPC-157 and thymosin beta-4 derivatives are increasingly used for musculoskeletal recovery, yet the available literature remains dominated by preclinical models with minimal human validation (Vasireddi et al