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188 A meta-analysis of 19 randomized placebo-controlled trials including 1,683 patients found that melatonin supplementation improved sleep quality, increased total sleep time, and decreased sleep latency

It is characterized by rapid neuronal death and extracellular matrix degradation post-injury, culminating in cavity formation and long-term neurological deficits (217, 218)

Due to the complexity of the kidney, as an organ containing specialized structures and multiple cell types, it becomes quite difficult to find a reliable model system to study the effects or toxicity of drugs and their metabolites on this organ

Tau protein hypothesis Besides the A protein deposition, hyperphosphorylated or abnormally phosphorylated Tau protein aggregated into neuronal neurofibrillary tangles is also one of the primary pathogeneses of AD [35,36,37]