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The results showed that the PGRMC1 dimer is not dissociated into monomer at all concentrations examined (Supplementary Fig

doi: 10.1056/NEJM198712313172706 10 MedinaMQuesadaA

10.3389/fneur.2015.00107 7

In addition, the oldest orphan nuclear receptor estrogen-related receptor (ERR), an important regulator of metabolic gene transcription and innate immune function, including those induced by toll-like receptor (TLR) and antimicrobial activities against intracellular bacterial infection [147], facilitated post-translational activation of autophagy by deacetylating various autophagy-related proteins, including ATG5, BECN1, and ATG7