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Retatrutide was developed as a successor compound to dual incretin agonists (such as tirzepatide), adding glucagon receptor agonism to the GLP-1/GIP profile

Given the critical role of CA1 neurons in the formation, consolidation, and retrieval of hippocampal-dependent memories [104, 105], we further investigated the region-specific role of HDAC9 in adult CA1 neurons using AAV-Cre-mediated gene knockdown