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Future studies should incorporate models with greater human relevance, including humanized mouse systems and patient-derived organoids, to more reliably evaluate drug exposure, toxicity and lactylation-dependent signaling

Results: Fourteen patients were enrolled (cell transplant group: 10, standard treatment group: 4)

After incubation, the compounds were titrated using an Echo acoustic dispenser (Labcyte) and the plate was further incubated for 24 h at 37 C and 5% CO 2

We measured systolic (SBP) and diastolic BP, BMI, plasma (NE pl ) and urine norepinephrine (NE u ), and plasma GSH in n =204 twins across the age spectrum