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Ferroptosis is mainly characterized by non-apoptotic iron-dependent cell death caused by iron-dependent lipid peroxide excess and is accompanied by abnormal iron metabolism and oxidative stress

doi: 10.3389/fimmu.2023.1156774 Received 01 February 2023 Accepted 26 June 2023 Published 11 July 2023 Volume 14 - 2023 Edited by Bowen Wu, Zhejiang University, China Reviewed by Xueping Li, Stanford University, United States

In different liver cancer cell lines, fluoxetine increases intracellular ROS levels and activates both intrinsic and extrinsic apoptotic pathways, promoting tumor cell apoptosis [225, 275]

BPC-157 addresses this directly through robust angiogenic effects mediated by the VEGFR2-Akt-eNOS pathway and nitric oxide production