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The anti-inflammatory potential of n-3 LCPUFAs is thought to involve peroxisome proliferator-activated receptor (PPAR)- activation and the cross-inhibition of NF-B signaling, alongside the generation of pro-resolving lipid mediators such as resolvins, protectins, and maresins, as well as Nrf2 activation, which counteracts oxidative stress and subsequent cytokine release (Valenzuela et al., 2016)

Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J (2007) QBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

The increased utilization of oxygen by neutrophils during or following phagocytosis is mostly related to the assembly and activation of the NADPH oxidase (NOX2) in the plasma membrane, but more importantly in the phagosomal membrane (which is derived from the plasma membrane) [77]

Given these roles, vitamin B6 deficiency can severely impact both the central and peripheral nervous systems (58)