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However, the relative absence of restrictions to date in the US has led e-cigarette marketing to permeate most media outlets through the likes of celebrity endorsements, images associated with youth culture, and statements encouraging consumers to reclaim lost freedoms "Impact of advertisements promoting candy-like flavoured e-cigarettes on appeal of tobacco smoking among children: an experimental study"

[21] Prenatal exposure to tobacco smoke is associated with a higher risk of attention deficit hyperactivity disorder (ADHD) in children, though it remains unclear whether the relationship is causal or reflects shared genetic and familial factors between parent and child

Indigenous peoples in the Americas smoked tobacco in pipes long before European contact

In this section, we briefly review some of these important factors before highlighting current findings on the neurobiology of this comorbidity