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By purchasing this material, you acknowledge that it will be used only by qualified individuals in accordance with applicable laws, regulations, and accepted laboratory practices.

The body uses them as signalling molecules

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The simulated magnitude of the interaction (AUCR, 1.02) with midazolam was ~30% lower than observed (AUCR, 1.39) if only reversible CYP3A inhibition was considered, indicating that time-dependent inhibition contributes to the mechanism of the interaction