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Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive

Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly

Free radicals are highly reactive and unstable molecules or atoms with at least one unpaired electron in their outermost shell

Nevertheless, the level of glutathione in the body tends to decrease with age, consequently making the cells more prone to oxidative damage and contributing to cellular ageing