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475 Aberrant and premature developmental gliogenesis (which ultimately affects both neurones and glia) lies at the core of the cellular pathophysiology of Down syndrome

Overall they were mild or moderate and only a small proportion of patients had to discontinue the treatment.14 Given these results, mannitol was also tested on non-CF BE and even though the first studies were carried out on small groups of patients, during short periods of time and mostly relating to non-clinical issues, they showed promising results of its use in this patient population.11 An open-label study of mannitol (400mg), carried out on 9 patients with BE, once daily, during a 12-day period documented a highly significant improvement in quality of life, which is assessed by St George's Respiratory Questionnaire (SGRQ), and maintained for 610 days after cessation of treatment

However, there is a difference in polyphagia or high host specificity