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The sequence parameters included a TE of 80 ms, TR of 2,000 ms, water suppression using a multiple optimized insensitive suppression train, pulse duration of 20 ms, an estimated water peak of 4.68 ppm, editing pulses interleaved at 1.9 ppm (ON) and 1.5 ppm (OFF), averaging two signals, a phase cycle of 16, frequency stabilization, and a total of 160 dynamic scans

When the tumor reached 100150 mm 2 , mice were divided into three groups following the principle of randomness and respectively received subcutaneous Intraperitoneal injection every two days with Tween80 (vehicle control, 100 l), GSPT1 inhibitor (HY135318