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Studies have shown that long-term use of proton pump inhibitors (PPIs) upregulates MLCK expression via a p38 MAPK-dependent pathway, exacerbating experimental colitis [83]

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doi:10.1186/1476-511X-9-50 Cai J, Yang L, He HJ, Xu T, Liu HB, Wu Q, Ma Y, Liu QH, Nie MH (2014) Antioxidant capacity responsible for a hypocholesterolemia is independent of dietary cholesterol in adult rats fed rice protein