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After US irradiation, the sonosensitizer Ce6 produces extensive amounts of intracellular ROS to trigger PBSN38 activation and release the active SN38, thereby inducing tumor cell apoptosis in a temporal- and spatial-controllable manner and realizing potent antitumor activity (Scheme 1C)

[5] The International Union of Pure and Applied Chemistry (IUPAC) defines "coenzyme" a little differently, namely as a low-molecular-weight, non-protein organic compound that is loosely attached, participating in enzymatic reactions as a dissociable carrier of chemical groups or electrons