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PGD 2 production in DMD is involved in the expansion of muscular necrosis caused by muscular inflammation based on the observation that the administration of HPGDS inhibitors, including HQL79, TAS204, and TAS205, ameliorates muscular atrophy by decreasing urinary tetranor-PGDM concentrations in animal models 10,19,20,21 and in patients with DMD 22,23

Prostaglandin Inhibition and a Weakened Mucosal Barrier The main pharmacological action of corticosteroids is blocking the cyclooxygenase pathway, often called the COX pathway

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Kanehisa M., Sato Y., Furumichi M., Morishima K., Tanabe M

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