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Low B12 levels can lead to megaloblastic anemia, a condition where red blood cells are abnormally large and unable to transport oxygen efficiently, causing symptoms like fatigue, weakness, and breathlessness

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Expression of Cyp7a1, the rate-limiting enzyme of BA synthesis, was significantly increased by re-feeding similarly in WT/ND mice and Insr P1195L/ +/ND mice, while that in WT/HFD mice was significantly elevated under fasted condition and did not show further increase by re-feeding