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When conjugated with a hemiasterlin analog (KT886) to form VDC886, it exhibited strong in vitro cytotoxicity against 33 cancerous cell lines which include melanoma (C3 human and B16 murine cell lines), glioma, human mammary cancer (4T1 and MDA-MB-231 cancerous cell lines), lymphoma (MyLa2059 T-cell line), and human colon cancer cell line (Colo 205) at inhibitory concentrations 50 (IC50) between 0.2 pM to 30 nM

Schechter AN, Gladwin MT (2003) Hemoglobin and the paracrine and endocrine functions of nitric oxide

If a cat is very unwell or has been sick for some time, establishing their FIV/FeLV status is advisable since these viruses can cause a variety of problems, including weakening their immune system and making them more prone to infections or certain types of cancer

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