Total result is illustrated in and in the weight of target organ, feces, urine or blood flow volume, does not have significant difference between the group.In urine, do not detect the test sample of significant quantity.Do not collect urine from group I (contrast), II (the 0th hour) or VI (the 12nd hour).Except group VII (after the administration 18 hours), in research process, go up the test sample that in blood, does not detect significant quantity at any time.For group V (after the administration 8 hours), record the maximum amount of picocurie/gram tissue and picocurie/mL, find to be somebody's turn to do and measure the most concentrated in feces and pancreas on this time.Also in the liver of group V, find picocurie level/gram tissue of increase.In liver, after edging down in the 12nd hour, level was kept constant and in liver, is found suitable level for group IX (the 7th day animal) at the 18th and 24 hour.After reaching peak value on the 8th hour after the administration, the pancreas amount is reduced near 0 level, comprises group IX result.The spleen amount rose at the 4th hour, dropped near 0 level during subsequently by the 18th hour.Yet increase for this tittle of group IX, it is tired at splenic dyspepsia to be illustrated in the 7th day test sample.There is test sample or supplies the percutaneous of the metabolite of examination material to absorb, because in liver and pancreas, find said chemical compound.The confession examination material that does not have significant quantity curiously in the blood is because the transportation route of expection is a blood flow.Possible explanation is that test sample passes through liver and pancreas is removed from blood fast.Another kind possibly be that test sample can directly be taken in (through licking medicament itself or licking and grab the pawl that nuzzles up in the administration position) by animal
Karki R, Kanneganti T-D
Specialized pro-resolving lipid mediators in the inflammatory response: an update
Changes in cilia, rather than mucin function, therefore, may contribute to the aberrant surface topology observed
