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Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M 1 -preferring receptor agonists

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37 In our study, we found that Clopidogrel downregulated the expression of phosphorylated eNOS and induced ER stress in the rat gastric mucosa cells and the BPC 157 protected against Clopidogrel-induced gastric mucosa dysfunction by alleviating ER stress and promoting eNOS -mediated angiogenesis whereas the effect of L-NAME is completely the opposite