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We used CCW16, an RNF4-binding moiety [39], as a starting point for a focused small-molecule screen and identified an RNF4 binder with higher affinity (R4B), which served as a building block for developing more potent R4VPs

These internal proteins contain a characteristic N-terminal signal sequence that directs their packaging into the capsid 27 , and they are injected into the host cell along with phage DNA at the onset of infection 28

Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX-2-derived prostanoids

Vigorously wipe both rubber stoppers with a fresh alcohol prep pad and allow them to air dry for about 30 seconds