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Comparative analyses further highlight these source-dependent disparities, revealing that the chondrogenic potential of both BMSCs and AD-MSCs in the presence of TGF-3 exceeds that of annulus fibrosus-derived MSCs (AF-MSCs) (Park et al., 2011b)

The higher prevalence of both anemia and OWOB in adolescent girls, compared with that in boys, could be explainable by the higher consumption of energy-dense foods (sweets, cakes and donuts, burgers, French fries, and hot dogs), lower consumption of fruits and vegetables 48,49,57,58 , lower consumption of iron rich foods such as animal protein 59 , and lack of physical activity 48

Acknowledgments We express our appreciation for the guidance received from the late Roberto Milanino, MD, of the University of Verona, who brought insight into the biological relevance of our research and to whose memory we dedicate this manuscript

It is commonly accepted that it takes four to five half-lives to reach steady state, as shown in the figure to the right