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The RSPCA believes that, wherever animals are being considered for use in research, the humane research principles of replacement (non-animal alternatives to be used), reduction (minimum number of animals used) and refinement (procedures to minimise pain and suffering are implemented), known as the Three Rs [4], must be adhered to

Some of the earliest lighters, meanwhile, date back to the 17th century and were modified versions of flintlock pistols, but instead of igniting gunpowder (and launching a bullet), they ignited tinder

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