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High concentrations of guanidine hydrochloride (0.4 M) reversibly inhibit the peroxidase-like activity of Fe 3 O 4 by competing with H 2 O 2 for iron atoms 171

doi: 10.1038/s41586-019-1006-9 60 GuoP.MaX.ZhaoW.HuaiW.LiT.QiuY.et al

DHFR then catalyses the reduction of DHF back to THF in order to fuel further cycles of thymidylate synthesis

CBS selectively replenishes the GSH levels under cystine-restricted conditions Multiple critical enzymes are involved in the normal function of the TSS pathway, including CBS and CSE, which catalyze the first two steps of de novo cysteine generation, from homocysteine to cystathionine and then cysteine