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Mast cells are mainly found in the bone marrow and play a role in innate immunity as well as in neurogenic and autoimmune responses (Sant et al., 2007

CNTF is one of the most studied neurotrophic factors in the eye, and it has many neuroprotective effects on photoreceptors, retinal nerve fiber, and ganglion ( In addition, long-term delivery of encapsulated CNTF reversed cognitive impairment in animal models of Alzheimers disease ( Given the strong association between retinal dysfunction and cognitive impairment, we will further discuss this association in schizophrenia and autism spectrum disorders