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Additionally, rare loss-of-function germline mutations of Kelch-like ECH-associated protein 1 (KEAP1) could be detected in nodular goitre leading to Nrf2 pathway activation that favours transcription of cytoprotective and antioxidant enzymes (92)

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Change history 28 October 2014 This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication References Armstrong AJ, Garrett-Mayer E, Ou Yang YC, Carducci MA, Tannock I, de Wit R, Eisenberger M (2007) Prostate-specific antigen and pain surrogacy analysis in metastatic hormone-refractory prostate cancer

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