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NPG members searched the Pubmed database from 2014 to 2024 using specific keywords for selected pharmacological and non-pharmacological treatments (Table 1) with the following filters: Clinical trial, Phase I, II, III, Randomized controlled trial

It significantly downregulated pro-apoptotic proteins Bax and caspase-3, while upregulating the anti-apoptotic protein Bcl-2, thereby reducing mitochondrial Cyt C release