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Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1

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Disclosures: Fajuan Rui: Nothing to Disclose, Yee Hui Yeo: Nothing to Disclose, Wenjing Ni: Nothing to Disclose, Liang Xu: Nothing to Disclose, Qi Zheng: Nothing to Disclose, Youwen Tan: Nothing to Disclose, Qing-Lei Zeng: Nothing to Disclose, Ming-Hua Zheng: Nothing to Disclose, Zebao He: Nothing to Disclose, Yuanwang Qiu: Nothing to Disclose, chuanwu zhu: Nothing to Disclose, Chao Wu: Nothing to Disclose, Yuemin Nan: Nothing to Disclose, Junping Shi: Nothing to Disclose, Jie Li: Nothing to Disclose 427 CHARACTERIZATION OF HDV RNA AND HBSAG DURING PEGYLATED INTERFERON-ALPHA AND RITONAVIR-BOOSTED LONAFARNIB COMBINATION THERAPY: THE D-LIVR STUDY Leeor Hershkovich 1 Harel Dahari 1 Scott Cotler 2 Theo Heller 3 Christopher Koh 3 Jeffrey Glenn 4 Tarik Asselah 5 Saeed Hamid 6 Ohad Etzion 7 , 1 Loyola University Chicago, 2 Loyola University Health System, 3 Liver Disease Branch, NIDDK, NIH, 4 Stanford School of Medicine, 5 Hpital Beaujon, 6 Aga Khan University, 7 Soroka University Medical Center Background: Understanding of the kinetic profiles of hepatitis D virus (HDV) and hepatitis B surface antigen (HBsAg) during pegylated-interferon--2a (pegIFN) and ritonavir-boosted lonafarnib (LNF) therapy is lacking