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In addition, when bacterial infection occurs, macrophages secrete more EVs, which contain iron uptake receptors that combine with ferric proteins in the circulation to reduce bacterial iron utilization, thus interfering with iron metabolism and achieving antibacterial effects [162]

Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Crystals were soaked in mother liquor supplemented with 15% glycerol and flash frozen in liquid nitrogen prior to data collection

Icariin II (ICS II), a flavonoid from Epimedium koreanum , triggers ferroptosis in renal carcinoma by downregulating GPX4 in a p53-independent manner and upregulating miR-324-3p, which suppresses GPX4 expression, leading to iron accumulation, lipid peroxidation, and GSH depletion (234)