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Sutomo R, Laosombat V, Sadewa AH, Yokoyama N, Nakamura H, Matsuo M et al

Under chronic stress, astrocytes adopt a neurotoxic A1 phenotype, characterized by downregulated autophagy genes (SQSTM1, MAP1LC3B) and loss of neurotrophic support

In combination with ciprofloxacin, it can enhance the antioxidant effect of ciprofloxacin and reduce its toxic effect, which may provide potential benefits against AD by regulating ferroptosis