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For example, ferroptosis sensitivity can be increased by overexpression of TfR, which enhances iron uptake, and by decreased expression of FTH1 and FTL, which lowers ferritin levels and thereby reduces iron storage [25]

Combination strategies further enhance therapeutic efficacy: pairing metabolic inhibitors with chemotherapy (such as PKM2 inhibitors combined with 5-FU), immunotherapy (including IDO1 inhibitors used in conjunction with anti-PD-L1 agents), or radiotherapy (for example, SCD1 inhibitors administered alongside ferroptosis inducers) can synergistically amplify anti-tumor effects

Evidence supports an association between the diseases, but the exact underlying mechanisms behind the connection are still under investigation

Servicebio Technology) according to the manufacturers instructions