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Plasma cysteine, cystine, and glutathione in cirrhosis

For instance, targeting key metabolic enzymes or using glycolysis inhibitors can reduce lactate production and lactylation levels, thereby enhancing the efficacy of immune checkpoint blockade therapy, improving NK and CD8+ T cell infiltration and counteracting the regulatory T cell expansion caused by MOESIN-K72la (82)

Treatment with propargylglycine (PAG) [16], a pharmacological inhibitor of the key enzyme in the transsulfuration pathway that catalyzes the hydrolysis of cystathionine into cysteine, cystathionine -lyase (CSE), was sufficient to sensitize two MYCN -amplified NB cell lines to system Xc-inhibition ( Fig

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