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Several genes associated with vitiligo are located in the HLA region, which induces an autoimmune response owing to self-antigens that activate T cells

Primarily, Al toxicity is initiated with root degeneration where a turnover of cellular redox into more oxidized state or establishment of oxidative burst is ensured

To balance these characteristics, Zhao and colleagues (115) developed a discretely integrated nanofabrication (DIN) platform combining cisplatin, ICG, and a polymeric spacer (PES)

These interventions resulted in notable improvements in ATP synthase function and alleviated mitochondrial dysfunction, demonstrating the potential of mitochondria-targeted restriction endonucleases (mtREs) to prevent disease onset or reverse clinical symptoms in patients with specific pathogenic heteroplasmic mtDNA mutations