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The evidence for such a decline is strongest in the brain where glutathione loss is implicated in both Parkinsons disease and in neuronal injury following stroke. In fact, aging can result in a deficiency of glutathione, which can then lead to a number of other issues

Angstwurm, M

Figure 1 3.2

Drug Interactions: Patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of dopamine HCl should receive initial doses of 1/10th normal Tricyclic antidepressants may potentiate the pressor response to adrenergic agents Cardiac effects of dopamine are antagonized by beta-adrenergic blocking agents Haloperidol and haloperidol-like drugs suppress the dopaminergic renal and mesenteric vasodilation induced at low rates of dopamine infusion References: Biaggioni I (2024): Adrenoceptor Agonists & Sympathomimetic Drugs (Chapter 9)