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However, in high doses, methylene blue can paradoxically induce methemoglobinemia, the very condition it is meant to treat

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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

Crocetin protected human hepatocyte LO2 cell from TGF--Induced oxygen stress and apoptosis but promoted proliferation and autophagy via AMPK/m-TOR pathway