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Side Effects and Risks Folinic acid is generally safe, but side effects can occur: Common side effects (occur in 5-15% of children): Increased agitation or hyperactivity (paradoxical reaction) Aggression or irritability (worse before it gets better) Insomnia (trouble sleeping) Headache Nausea, stomach upset, diarrhea Appetite changes (increased or decreased) Serious but rare: Allergic reaction (rash, difficulty breathing seek immediate help) Masking of vitamin B12 deficiency (the most important risk) Beyond Medication Lifestyle and Dietary Changes Medication alone is often not enough

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Many researchers believe that restoring NAD levels could help enhance energy metabolism, support cognitive function, and improve overall cellular health

CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons