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These patients further exhibit increases in incidence, intensity, and duration of sensory neuropathy with repeated treatments

First, transition metal containing glyoxalase I catalyses the formation and isomerization of the hemithioacetal, which was formed spontaneously between glutathione (GSH) and -keto aldehydes, into ( S )--hydroxyacylglutathione

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3,5 The canonical NF-B pathway responds to diverse stimuli, including ligands of various cytokine receptors, pattern-recognition receptors (PRRs), TNF receptor (TNFR) superfamily members, as well as T-cell receptor (TCR) and B-cell receptor