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It was found by ELISA that HG elevated Carbonyl content in cardiomyocytes, while diminished GSH and SOD contents

Oxidative stress is a condition that occurs when the body's antioxidant defenses are overwhelmed by free radicals and reactive oxygen species

For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)

However, changes in nail structure, a sign of toxicity, were reported with a selenium intake of 900 mcg per day in China