the d-retro inverso dri isoform of foxo4 disordered p53 transactivation domain is the target and the senolytic compound FOXO4-DRI FOXO4 D-Retro-Inverso(DRI) peptide - Elabscience®
FOXO4 D Retro Inverso(DRI) peptide Elabscience FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells eBioMedicine FOXO transcription factors as therapeutic targets in human diseases: Trends in Pharmacological Sciences
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