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In metabolic tissues, particularly adipose and skeletal muscle, ROS impair insulin signaling by altering adipokine profiles (decreased adiponectin and increased leptin/resistin) and by inhibiting key signaling molecules like IRS-1 and GLUT4, resulting in systemic insulin resistance

In fact, the ratio of reduced glutathione to oxidized glutathione within cells is often used scientifically as a measure of cellular toxicity

Afterwards, the average of normalized MFR, NBR and NBD was calculated for every timepoint among the wells with the same experimental condition

Longitudinal analysis of somatic and germ-cell telomere dynamics in outbred mice