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PDas: Conceptualization, Data curation, Investigation, Methodology, Software, Visualization, Writing original draft

Generation of humanized zebrafish models for the in vivo assessment of antisense oligonucleotide-based splice modulation therapies

The sarcoplasmic reticulum Ca+ channel RyR2 undergoes SSG under oxidative stress, which initially protects against calcium overload in ischemia-reperfusion injury, whereas it becomes maladaptive in sustained oxidative environments (e.g., catecholamine-induced arrhythmias) (80)