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This enhanced MET signalling results from: (i) overexpression of MET [28,29,30,31,32,33,34,35,36], (ii) constitutive activation of MET [28, 29, 37], (iii) activation sustained by HGF [30, 37], and (iv) secretion of HGF, not normally expressed by epithelial cells, leading to an autocrine activation loop [28, 33, 34, 37]