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Most of phase 2 reactions take place in cytosol and involve conjugation with endogenous compounds via transferase enzymes

10.1080/13880209.2023.2225543 142 ScainiG.MasonB

Notably, during the early stages of treatment, TDNs@FLX synergistically promoted the proliferation of neural progenitor cells in the hippocampal dentate gyrus and enhanced neuronal plasticity, accelerating symptom relief and shortening the delayed onset typically observed with traditional antidepressants