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Transcriptional activity of forkhead box protein O3 (FOXO3) was reduced ( p = 0.0207) in hearts subjected to IRI, compared to aerobic control

Furthermore, persistent activation of the TCR and the type I IFN- signalling triggered mitochondrial changes via increasing NAD + consumption due to both CD38 overexpression and PARP activation in CD8 + T cells, resulting in lower spare respiratory capacity, decreased bioenergetic fitness and thus increased tendency to die

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