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Heres what researchers have learned recently about neurokinin B and hot flashes: Neurokinin B was identified in a genome-wide association study as the only gene that plays a significant role in hot flashes (vasomotor symptoms).[ref] Another strong indication that neurokinin B is integral to hot flashes is that when neurokinin B is given to young women by IV, it triggers hot flashes in 80% of the women.[ref] A placebo-controlled clinical trial of an NK3R (neurokinin B receptor) antagonist drug, which blocks the neurokinin B receptor, showed that it quickly reduced hot flash frequency by more than half compared to a placebo.[ref][ref] The emerging picture is that hot flashes involve body temperature mechanisms in the hypothalamus that are affected by estrogen and neurokinin B, which in turn affect FSH and LH levels

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Although results vary substantially between individuals, many before-and-after comparisons start showing noticeable improvements around the second month