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Together, they represent around 23.1 million disability-adjusted life-years (DALYs) globally, which translates to a loss of approximately 284.6 years per 100,000 population, with 28.02% of this increase in DALYs between 1990 and 2010 attributed to the aging population (Vollset et al., 2020

Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a drug-prodrug mechanism of action: A designed dual-acting melatonin-sulforaphane hybrid