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[11] There is insufficient evidence to conclude that B12 supplementation directly alters sleep architecture in healthy individuals with adequate B12 levels

Thermal Shift assays Tryptophan fluorescence measurements were carried out using Prometheus Panta (NanoTemper Technologies)

NAPstar3b was chosen as due to its K r(NADPH/NADP+) we expected it to be almost fully NADPH bound at steady state, therefore allowing for the maximum possible deflection upon NADP oxidation, and due to its particularly low NADH binding affinity

This finding further supports the safety and biocompatibility of RGD-GHK in potential applications