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A glutation kpes megvdeni a mitokondriumokat a krosodsoktl

10.1038/nphys3621 136 VermesI.HaanenC.Steffens-NakkenH.ReutellingspergerC

3.1.3 Mechanistic insights Metformin preserves mitochondrial integrity, a key determinant of I/R injury, by stabilizing membrane potential, inhibiting complex I during early reperfusion and preventing mitochondrial permeability transition pore (mPTP) opening, thus limiting ROS generation and apoptosis (Osorio-Llanes et al., 2023