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What Happens to Your Body, When You Take a Puff of a Cigarette? Keck Medicine of USC Smoking might feel calming in the moment, but that relief is temporary. As nicotine leaves your system, it can trigger stress and anxiety, keeping the cycle going. Breaking the cycle can actually Smokers often turn to cigarettes to feel calm when they're stressed. And there are two reasons for this First, nicotine has an anxiolytic effect by increasing the neurochemical GABA, which does tobacco relax you do cigarettes make you relax What to Do If You're Craving

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