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In models of water deprivation, puerarin promotes AVP release from the hypothalamic supraoptic nucleus and enhances vasopressin receptor responsiveness in collecting duct epithelia

doi: 10.1016/j.foodchem.2023.138214 229 WangB.SuX.WangT.YangT.XuC.LinZ.et al

NLRP3 inflammasome activation triggers Caspase-1-mediated mitochondrial damage, characterized by increased mtROS production, mitochondrial swelling, and fragmentation, while also inhibiting mitophagy and amplifying mitochondrial damage [11]